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CalmerThanYouAre
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Discussion Starter · #1 ·
This is a pretty important find for possible pharmaceutical applications.

Research Team Finds How CBD, a Component in Marijuana, Works Within Cells

The findings published in the Journal of Biological Chemistry could provide a new basis for developing CBD-based treatments for pediatric epilepsy

STONY BROOK, N.Y., February 11, 2015 – A team of Stony Brook University researchers have identified fatty acid binding proteins (FABPs) as intracellular transporters for two ingredients in marijuana, THC and CBD (cannabidiol). The finding, published early online in the Journal of Biological Chemistry, is significant because it helps explain how CBD works within the cells. Recent clinical findings have shown that CBD may help reduce seizures and could be a potential new medicine to treat pediatric treatment-resistant epilepsy.


CBD differs from THC in that it is not psychoactive and does not bind to cannabinoid receptors. Some children who are resistant to conventional antiepileptic drugs have been reported to show improvement with oral CBD treatment. The Stony Brook research team found that three brain FABPs carry THC and CBD from the cell membrane to the interior of the cell. This action enabled them to conduct experiments inhibiting FABPs and thereby reducing anandamide breakdown inside the cells.

“Anandamide, an endocannabinoid, has been shown to have neuroprotective effects against seizures in basic research studies and this may turn out to be a key mechanism of seizure control,” explained Dale Deutsch, PhD, Professor of Biochemistry and Cell Biology and a faculty member of the Institute of Chemical Biology and Drug Discovery at Stony Brook University. “Therefore by CBD inhibiting FABPs, we could potentially raise the levels of anandamide in the brain’s synapses.”

The findings in the paper, titled “Fatty Acid Binding Proteins are Intracellular Carriers for THC and CBD,” stem from the team’s research that spans five years and includes their discoveries that showed anandamide levels were raised in rodent brains using novel drugs targeted to FABPs. In 2013, they received a $3.8 million grant from the National Institute on Drug Abuse, part of the National Institutes of Health (NIH), to target endocannabinoid transporters to develop drugs for pain and inflammation.

The current research involving FABPs as transporters of CBD involves the work of faculty and students from several Stony Brook Departments. The team includes four Professors – Dr. Deutsch, Martin Kaczocha (Anesthesiology), Iwao Ojima (Chemistry and the Institute of Chemical Biology and Drug Discovery), and Stella Tsirka (Pharmacological Sciences). The team also features a post-doctoral fellow (Jeremy Miyauchi in Pharmacological Sciences), a researcher who recently received his PhD (William Berger in Chemistry), a graduate student Matthew Elmes, a research technician Liqun Wang, and undergraduate students Brian Ralph, Kwan-Knok Leung, and Joseph Sweeney, all from the Department of Biochemistry and Cell Biology.

http://www.newswise.com/articles/view/629638/?sc=rsmn
 

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Comfortably Numb
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Sooner or later the views/laws against marijuana are going to change for the better. I've seen the news and research becoming more positive for almost 4 decades now. The time has come.
 

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And the people saying thc is the answers will be ignored
 

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CalmerThanYouAre
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Discussion Starter · #4 ·
And the people saying thc is the answers will be ignored
Well, THC has shown promise. Marinol is an example. While it doesn't have all the benefits as the whole plant it's a start I guess.

I want a reliable source to treat my ailments that's consistent, tested clean and regulated.
 

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Comfortably Numb
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I have some ailments but I want to enjoy weed as I would a drink at home. It did help quite a bit while I was on Chemo.
 

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CalmerThanYouAre
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Discussion Starter · #6 ·
I have some ailments but I want to enjoy weed as I would a drink at home. It did help quite a bit while I was on Chemo.
I'll bring some cookies down but lets hope for no more chemo.
 

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Comfortably Numb
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12,273 Posts
I'll bring some cookies down but lets hope for no more chemo.
:bounce::bounce::bounce::bounce: still in remission. knock on my Rubi.:gluging:
 

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Banned
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Thank you, it was very interesting to read this text and understand something for yourself. I myself am a fan of marijuana and cbd oils, so this article seems quite familiar to me. I have been Smoking marijuana for five years now, as I often have an exacerbation of depression, and https://urbanaroma.com/dc-marijuana-delivery/ the only way that relieves stress and eliminates the anxiety that often occurs with depression. Many people have a negative attitude to weed, but for sure these are the people who just haven't tried a quality product in their life
 
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