Well, pulled the spare tire and removed the existing grommet on the right side (passenger) of the tire mount and could see straight through to the sheet metal...good news.
So, 4 rubber well-nuts later, I had my tuner ready to mount, and a quick cut with the hole saw and I had a nice opening to run the wire straight through the door. Used a PCV valve grommet from the local auto parts store to protect the edges. I'll add some foam of some sort to lock the wire centered in place.
I still have to permanently mount the radio and remote mount the control head, and am still waiting for my Teraflex antenna mount. Temporarily connected the radio, and made an instant connection to North Dakota on 20m with a 30' wire I threw up into the tree by my driveway.
Found an excellent RF/electrical ground using the torx bolt holding the cargo loops near the tailgate.
Pics to follow up shortly.