The Glock minis (26 and up) are far more concealable, but for home protection, size should be irrelevant. Well, in terms of concealment, it matters, but at home, you don't need to hide it (unless your wife's anti-gun, and then you're just screwed).
Aren't we all supposed to just have a double-barrel to shoot out the door randomly for home defense anyways?
All kidding aside, the 10mm is a rather uncommon round, and NOT anywhere on my top 10 list for home defense, largely for that reason. Glocks don't like handloads (at least Glock doesn't), and that pushes it further down the list (DO NOT USE HANDLOADS FOR HOME DEFENSE! Potential legal issues that aren't worth the risk, yada yada yada).
If you are looking for a Glock for concealed carry, the 36 is where it's at- .45 ACP, single stack magazine (relatively skinny, for a Glock), and easy to control. Yes, muzzle control comes with practice, but starting with a mid-size 10mm would be like learning to drive on a hot Corvette- sure, you can, but there are far smarter places to start.
If you are looking for a Glock that'll just hold down the bedside table, a 21 is your best bet. Again, .45 ACP, but full size- no concealment worries at home, as I mentioned. The full size frame means less recoil, so you can more easily place your follow-up shots, and be more likely to hit with every round (Lord willing) if you ever need to. They're not overly heavy, and they're plentiful, and so is ammunition.
Of course, without knowing where you live, all of this is just conjecture, as local laws (like if you're here in NYS) may throw much of this out- Mark W.