Yes. There are three wires to the switch(located at the master cylendar). 1-??-Cruise, 2-Yellow/Orange-start interlock, 3-Black-ground.
If you ground the yellow/orange wire the PCM will always think the clutch is pressed in and it will defeat the system. HOWEVER, I am finding mixed info on whether the cruise really uses pin 1 or if it uses pin 2 along with the starter override, so it's possible by doing this your cruise will no longer work. Wouldn't hurt to try.
There is also a relay that is triggered in 4 low that does the same thing.
You could always wire up a switch in the dash or wherever that grounds out pin 2 for the starter override and then you can just turn it "off" when you want to use cruise. Not sure if the PCM cares about the clutch for any other reason or if it will set any codes, but chances are pretty good if it sets a code against the clutch switch it won't turn the MIL on anyway.
Or you can just put it in 4 low and the switch is bypassed via the relay.
I assume you're wanting to put remote start on? Just don't leave it in gear